| The common isoform, FKBP12, was found to be associated with the calcium release channel ryanodine receptor 1 of different species of vertebrate skeletal muscle, whereas 12 | In this study, cardiac microsomes were isolated from diverse vertebrates: human, rabbit, rat, mice, dog, chicken, frog, and fish and were analyzed for their ability to bind or exchange with FKBP isoforms 12 and 12 |
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| FK506 binding protein FKBP is a cytosolic receptor for the immunosuppressive drug FK-506 | Our studies indicate that RyR2 from seven out of the eight animals contain both FKBP12 and 12 |
It can now be concluded that the association of FKBP isoforms with RyR2 is widely conserved in the hearts of different species of vertebrates.
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